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DiscoveRx has two approaches for monitoring the activity of Nuclear Hormone Receptors. The Nuclear Translocation assays monitor movement of a cytoplasmic NHR to the nuclear compartment. In the second approach, the Protein Interaction Assays detect NHR interaction with a co-activator fusion protein. This direct, non imaging approach provides feasibility of antagonist screening, fewer off-target effects, and the ability to select novel chemotypes based on disruption of protein-protein interactions.
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